pI: 10.5083 |
Length (AA): 451 |
MW (Da): 50726 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
238 | 297 | 3afp (A) | 17 | 98 | 35.00 | 0.76 | 0.27 | 0.208438 | 0.84 |
334 | 401 | 1kb2 (A) | 43 | 105 | 30.00 | 0.65 | 0.11 | 0.377176 | 0.07 |
359 | 442 | 1wde (A) | 57 | 142 | 33.00 | 0.51 | 0.02 | 0.352653 | 0.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst. | Gregory Hehl AB Fritz HM |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_127980)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G05590 | hypothetical protein |
Arabidopsis thaliana | AT4G22310 | hypothetical protein |
Babesia bovis | BBOV_III001040 | conserved hypothetical protein |
Brugia malayi | Bm1_48080 | Hypothetical UPF0041 protein F53F10.3 in chromosome I, putative |
Candida albicans | CaO19.6435 | similar to S. cerevisiae FMP43 (YGR243W) mitochondrial protein and to YHR162W |
Candida albicans | CaO19.13793 | similar to S. cerevisiae FMP43 (YGR243W) mitochondrial protein and to YHR162W |
Caenorhabditis elegans | CELE_F53F10.3 | Protein F53F10.3 |
Dictyostelium discoideum | DDB_G0268478 | UPF0041 family protein |
Drosophila melanogaster | Dmel_CG9399 | CG9399 gene product from transcript CG9399-RE |
Drosophila melanogaster | Dmel_CG9396 | CG9396 gene product from transcript CG9396-RA |
Drosophila melanogaster | Dmel_CG32832 | CG32832 gene product from transcript CG32832-RB |
Echinococcus granulosus | EgrG_000090100 | brain protein 44 |
Echinococcus multilocularis | EmuJ_000090100 | brain protein 44 |
Homo sapiens | ENSG00000143158 | mitochondrial pyruvate carrier 2 |
Leishmania braziliensis | LbrM.14.1650 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_141560.1 | Mitochondrial pyruvate carrier 2 |
Leishmania infantum | LinJ.14.1560 | hypothetical protein, conserved |
Leishmania major | LmjF.14.1460 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.1460 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000026568 | mitochondrial pyruvate carrier 2 |
Neospora caninum | NCLIV_020880 | hypothetical protein |
Oryza sativa | 4343123 | Os07g0449100 |
Oryza sativa | 4345333 | Os08g0344300 |
Onchocerca volvulus | OVOC1107 | Putative mitochondrial pyruvate carrier 1 |
Onchocerca volvulus | OVOC1106 | Putative mitochondrial pyruvate carrier 1 |
Plasmodium berghei | PBANKA_1333600 | mitochondrial pyruvate carrier protein 2, putative |
Plasmodium falciparum | PF3D7_1470400 | mitochondrial pyruvate carrier protein 2, putative |
Plasmodium knowlesi | PKNH_1210600 | mitochondrial pyruvate carrier protein 2, putative |
Plasmodium vivax | PVX_116950 | mitochondrial pyruvate carrier protein 2, putative |
Plasmodium yoelii | PY06652 | Arabidopsis thaliana At4g22310-related |
Saccharomyces cerevisiae | YGR243W | Fmp43p |
Saccharomyces cerevisiae | YHR162W | Mpc2p |
Schistosoma japonicum | Sjp_0215730 | Brain protein 44, putative |
Schistosoma mansoni | Smp_099420 | hypothetical protein |
Schmidtea mediterranea | mk4.001627.09 | Probable mitochondrial pyruvate carrier 1 |
Schmidtea mediterranea | mk4.001149.09 | |
Trypanosoma brucei gambiense | Tbg972.7.3870 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.3520 | Mitochondrial pyruvate carrier 2 |
Trypanosoma congolense | TcIL3000_7_2740 | Mitochondrial pyruvate carrier 2 |
Trypanosoma cruzi | TcCLB.508265.44 | Mitochondrial pyruvate carrier 2 |
Trypanosoma cruzi | TcCLB.506443.40 | Mitochondrial pyruvate carrier 2 |
Toxoplasma gondii | TGME49_204370 | WD-40 repeat protein |
Toxoplasma gondii | TGME49_245748 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3520 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.3520 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_204370 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_245748 this record | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.